Magnesium interrelationships in ischemic heart disease: a review.

Magnesium ions are essential for the maintenance of the functional and structural integ· rity of the myocardium. Experimental magnesium deficiency induces cardiac necrosis and enhances susceptibility to cardiotoxic agents; magnesium administration is protective. Recent investigations indicate that cellular loss of magnesium may be a basic biochemical mechanism in the evolution of myocardial lesions of diverse etiology. Other studies have shown that magnesium depletion influences coronary flow, blood clotting, and atherogenesis. This paper surveys the cardiovascular role of magnesium as it relates to certain facets of ischemic heart disease.